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​(1)  Grape Seed Extract is Antibacterial, Antiviral, Anticarcinogenic, Anti-inflammatory, and Anti-allergic; Alternative Medicine Review (Apr.5 2000According to the Alternative Medicine Review, considerable recent research has explored therapeutic applications of oligomeric proanthocyanidin complexes (OPCs). These compounds have demonstrated antibacterial, antiviral, anticarcinogenic, anti-inflammatory, and anti-allergic. (1) Grape Seed Extract is a Powerful Antioxidant for Anti-aging. The Journal of Medicinal Food (Dec 2003) – The Journal of Medicine Food found that Grape seed extract contain (oligomeric proanthocyanidins) which is a powerful antioxidant that protects the body from premature aging, disease and decay. 

(2) Grape Seed Extract More Powerful than Vitamin C and E for Disease Prevention; Toxicology (Aug 7, 2000) - University School of Pharmacy & Allied Health Professions concluded that Grape Seed Extract (GSPE) provided significantly better protection as compared to vitamins C and E. GSPE also demonstrated excellent protection against acetaminophen overdose-induced liver and kidney damage.

(3) Grape Seed Extract Increases Skin Hydration; Skin Pharmacol Appl Skin Physiol (Oct. 2010) - The regular use of products with oligomeric proanthocyanidins may help to protect your skin from free-radical-mediated skin inflammation to increase skin hydration and elasticity.

(4) Grape Seed Extract Has Antiulcer Activity; J. Agric. Food Chem;  (Mar. 1998) – A Japanese study was conducted to see the antiulcer activities of grape seed extracs and procyanidins. It was shown that Grape Seeds had powerful antiulcer activity. The study suggests that this may be due to the protection by radical scavenging activity of Grape Seed on the stomach surface against radical injury. 

(5) Grape Seed Extract Helps Reduce the Risk of Heart Disease; ScienceDaily (Nov. 1 2008) — A growing body of research data suggests that consuming foods rich in polyphenols from grapes, including red wine according to a review article in the November issue of Nutrition Research. The authors review the accumulating evidence that grape polyphenols work in many different ways to prevent cardiovascular and other "inflammatory-mediated" diseases.  

(6) Grape Seed Extract Kills Head and Neck Cancer Cells, Leaves Healthy Cells Unharmed; ScienceDaily (Jan. 27, 2012) —A study published in the journal Carcinogenesis, shows that in both cell lines and mouse models, grape seed extract (GSE) kills head and neck squamous cell carcinoma cells, while leaving healthy cells unharmed. 

(7) Grape Seed Extract Induces Cell Cycle Arrest and Apoptosis in Human Colon Carcinoma cells; Nutrition and Cancer (2008) – The findings suggest that GSE could be an effective agent against colon cancer cells possibly due to its strong growth inhibitory and apoptosis-inducing effects.

(8) Grape Seed Extract Induces Apoptotic Death of Human Prostate Carcinoma; Carcinogenesis. (Nov. 2002) - Our studies showed that GSE inhibits growth and induces apoptotic death of human prostrate cells. Prostate cancer chemoprevention is an alternative and potential strategy to control this malignancy.

(9) Grape Seed Extract Hopeful in Human Acute Myeloid Leukaemia; Anticancer research (2009 Jan; 29) - Aaccording to a study published in the January 2009 issue of "Clinical Cancer Research", Grape seed extract induces the programmed cell death of human leukemia cells in the laboratory by activating the enzymes of the apoptosis pathways. An additional study published in the March 2005 issue of the "Chinese Medical Journal" also reported that grape seed extract promotes the death of human acute myeloid leukemia cells in the laboratory. 

(10) Grape Seed Extract and Other Grape-Based Products Anticancer and Cancer Chemopreventive Potential; The Journal of Nutrition (Dec 8 2008) - Grapes and grape-based products are in a class of dietary products that have shown cancer chemopreventive potential and are also known to improve overall human health. Overall, completed studies from various scientific groups conclude that both grapes and grape-based products are excellent sources of various anticancer agents and their regular consumption should thus be beneficial to the general population. 

(11) Grape Seed Extract has Antibacterial Properties; J. of Toxicol Sci. (2010) - The considerable antibacterial activity of commonly available grape seed extract could signify a major advancement in the treatment of MRSA diseases. This study was conducted to measure the antibacterial activity of grape (Vitis vinifera L; Vitaceae) seed extract against methicillin-resistant Staphylococcus aureus (MRSA). 

(12) Grape Seed Extract (Polyphenols) Able to Inhibit Amyloid-beta (Abeta) Aggregation in Alzheimer’s; Neurotox Res. (2009 Jan.15) – This study suggests that polyphenol-rich GSE prevents the Abeta deposition and attenuates the inflammation in the brain, this is promising in delaying development of AD.

(13) Grape Seed Extract Reduces Inflammation to in Obesity and Type 2 Diabetics thus Reducing Heart Disease; J. Nutr. Biochem (Oct. 21 2010) Grape Seed Extract significantly improved markers of inflammation and glycaemia and a sole marker of oxidative stress in obese Type 2 diabetic subjects at high risk of cardiovascular events over a 4-week period, which suggests it may have a therapeutic role in decreasing cardiovascular risk.

(14) Grape Seed Extract Show Promising Anti-HIV Effects; Biological (2002) – This study suggests the anti-HIV-1 effects of grape seed extracts maybe useful in the prevention and/or amelioration of HIV-1 infection.

(15) Grape Seed Extract for Control of Human Enteric Viruses and Hepatitis A;  Appl Environ Microbiol.(Jun. 2011) - The results of this study indicate that Grape Seed Extract shows promise for application in the food industry as an inexpensive novel natural alternative to reduce viral contamination and enhance food safety.

1. Anne Marie Fine, CPA, ND Candidate 2000, Oligomeric Proanthocyanidin Complexes: History, Structure, and Phytopharmaceutical Applications.
Altern Med Rev. 2000 Apr;5(2):144-51.
2. Bagchi D, Bagchi M, Stohs SJ, Das DK, Ray SD, Kuszynski CA, Joshi SS, Pruess HG, Free radicals and grape seed proanthocyanidin extract: Importance in human health and disease prevention. Toxicology. 2000 Aug 7;148(2-3):187-97.
3. Hughes-Formella B, Wunderlich O, Williams R, 
Anti-Inflammatory and Skin-Hydrating Properties of a Dietary Supplement and Topical Formulations Containing Oligomeric Proanthocyanidins; 
Skin Pharmacol Appl Skin Physiol 2007;20:43–49 (DOI: 10.1159/000096171)
4. Makoto Saito ,* Hiroshi Hosoyama , Toshiaki Ariga , Shigehiro Kataoka , and Nobuyuki Yamaji , Antiulcer Activity of Grape Seed Extract and Procyanidins; Agric. Food Chem., 1998, 46 (4), pp 1460–1464. DOI: 10.1021/jf9709156, Publication Date (Web): March 19, 1998
5. Elsevier. "Grapes And Grape Extracts May Lower Cardiovascular Disease Risk, Review Article Suggests." ScienceDaily, 1 Nov. 2008. Web. 10 Oct. 2012.
6. Rajesh Agarwal , University of Colorado Denver. "Grape seed extract kills head and neck cancer cells, leaves healthy cells unharmed." ScienceDaily, 27 Jan. 2012. Web. 10 Oct. 2012.
7. Kaur M, Mandair R, Agarwal R, Agarwal C. Grape seed extract induces cell cycle arrest and apoptosis in human colon carcinoma cells.
Nutrition and Cancer. 2008;60 Suppl 1:2-11. Source: University of Colorado Denver, Denver, Colorado 80045, USA.
8. CAgarwal C, Singh RP, Agarwal R. Grape seed extract induces apoptotic death of human prostate carcinoma DU145 cells via caspases activation accompanied by dissipation of mitochondrial membrane potential and cytochrome c release; Carcinogenesis. 2002 Nov;23(11):1869-76. Source: Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO 80262, USA. 
9. Anticancer Res. 2009 Jan;29(1):283-9. Hu H, Qin YM. Grape seed proanthocyanidin extract induced mitochondria-associated apoptosis in human acute myeloid leukemia 14.3D10 cells. Chin Med J (Engl). 2006;119(5):417-21.
10. Kaur M, Agarwal C, Agarwal R. Anticancer and cancer chemopreventive potential of grape seed extract and other grape-based products; The Journal of Nutrition (Dec 8 2008)- Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado, Denver, CO 80045, USA.
11. Al-Habib A. Bactericidal effect of grape seed extract on methicillin resistant Staphylococcus aureus (MRSA). J Toxicol Sci. 2010 Jun;35(3):357-64.
13. Wang YJ, Thomas P, Zhong JH, Bi FF, Kosaraju S, Pollard A, Fenech M, Zhou XF. Consumption of g2ape seed extract prevents amyloid-beta deposition and attenuates inflammation in the brain of an Alzheimer's disease mouse. Neurotox Res. 2009;15(1):3-14.
13. Montagut G, Bladé C, Blay M, Fernández-Larrea J, Pujadas G, Salvadó MJ, Arola L, Pinent M, Ardévol A. Effects of a Grapeseed procyanidin extract (GSPE) on insulin resistance. J Nutr Biochem. 2010 Oct;21(10):961-7. Epub 2009 Dec 4. Source: Department of Biochemistry and Biotechnology, Rovira i Virgili University, Tarragona, 43007 Spain.
14. Nair MP, Kandaswami C, Mahajan S, Nair HN, Chawda R, Shanahan T, Schwartz SA. Grape seed extract proanthocyanidins downregulate HIV-1 entry coreceptors, CCR2b, CCR3 and CCR5 gene expression by normal peripheral blood mononuclear cells. Effects Biological Research. (2002);35(3-4):421-31.
15. Su X, D'Souza DH. Grape seed extract for control of human enteric viruses. Appl Environ Microbiol. 2011 Jun;77(12):3982-7. Epub 2011 Apr 15.

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