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Gluten sensitivity is actually an autoimmune disease that creates inflammation throughout the body, with wide-ranging effects across all organ systems including your brain, heart, joints, digestive tract, and more. It can be the single cause behind many different "diseases."In fact, a recent review in the New England Journal of Medicine listed fifty-five diseases that can be caused by eating gluten! 

(1) 55 "Diseases" That Can Be Caused by Eating Gluten. The New England Journal of Medicine.  Dr. Mark Hyman reports that a review paper in The New England Journal of Medicine listed 55 “diseases” that can be caused by eating gluten. These include osteoporosis, irritable bowel disease, inflammatory bowel disease, anemia, cancer, fatigue, canker sores, rheumatoid arthritis, lupus, multiple sclerosis, and almost all other autoimmune diseases. Gluten is also linked to many psychiatric and neurological diseases, including anxiety, depression, schizophrenia, dementia, migraines, epilepsy, and neuropathy (nerve damage). It has also been linked to autism.

(2) People With Gluten Sensitivity Had a Higher Risk of Death, Mostly from Heart Disease and Cancer. Journal of the American Medical Association ( 2008) - A recent large study in the Journal of the American Medical Association found that people with diagnosed, undiagnosed, and "latent" celiac disease or This study looked at almost 30,00 patients from 1969 to 2008 and examined deaths in three groups: Those with full-blown celiac disease, those with inflammation of their intestine but not full-blown celiac disease, and those with latent celiac disease or gluten sensitivity (elevated gluten antibodies but negative intestinal biopsy). The findings were dramatic. There was a 39 percent increased risk of death in those with celiac disease, 72 percent increased risk in those with gut inflammation related to gluten, and 35 percent increased risk in those with gluten sensitivity but no celiac disease. This is ground-breaking research that proves you don't have to have full-blown celiac disease with a positive intestinal biopsy (which is what conventional thinking tells us) to have serious health problems and complications. (Excerpts from Mark Hyman MD. Three Hidden Ways Wheat Makes You Fat (Feb. 18, 2012)

(3) Gluten Sensitivity Linked to Psychiatric Disorders. Gastroenterology.(Apr. 2005) Rrecent studies have concluded that a wider spectrum of neurologic syndromes may be the presenting with gluten sensitivity with or without intestinal pathology.

(4) Gluten Sensitivity Can Be Directly and Uniquely Toxic to the Brain. J Neurol Neurosurg Psychiatry (2002) ; Dr. Hadjivassiliou a recognized world authority on gluten sensitivity, has reported in the journal, The Lancet, that "gluten sensitivity can be primarily and at times, exclusively a neurological disease." That is, people can manifest gluten sensitivity by having issues with brain function without any gastrointestinal problems whatsoever.  

(5) The Benefits of a Gluten Free Dietary Intervention in the Treatment of Autistic Children; International Meeting for Autism Research - This is the first study to demonstrate inhibitory effects of food-derived opiod peptides on redox status and provides mechanistic support for the “Gut-Brain Hypothesis”. It reveals a rationale for the beneficial effect of a GF/CF dietary intervention in the treatment of autistic children, and may have general relevance for inflammatory bowel disorders in which gluten and/or casein intolerance plays a role. 

(6) The Role of Gluten in Dermatitis. N Engl J Med (1983) - Dermatitis herpetiformis is characterized by an itchy blistering rash. The lesions are typically distributed over the elbows, knees, and buttocks. This distribution is a clear sign of gluten intolerance

(1) Mark Hyman MD. Three Hidden Ways Wheat Makes You Fat (Feb. 18, 2012), http://www.huffingtonpost.com/dr-mark-hyman/wheat-gluten_b_1274872.htmldeath--from eating gluten.
(2) Rubio-Tapia A, Kyle RA, Kaplan EL, Johnson DR, Page W, Erdtmann F, Brantner TL, Kim WR, Phelps TK, Lahr BD, Zinsmeister AR, Melton LJ 3rd, Murray JA. Increased prevalence and mortality in undiagnosed celiac disease. Gastroenterology. 2009 Jul;137(1):88-93 
(3) Bushara KO. Neurologic presentation of celiac disease. Gastroenterology. 2005 Apr;128(4 Suppl 1):S92-7. Review.
(4) M Hadjivassiliou, R A Grünewald, G A B Davies-Jones. Gluten sensitivity as a neurological illness; J Neurol Neurosurg Psychiatry 2002;72:560-563 doi:10.1136/jnnp.72.5.560 Dhttp://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2896%2990540-1/abstract
(5) M. S. Trivedi , N. Hodgson , R. Deth International Meeting for Autism Research: Morphine and Gluten/Casein-Derived Opiate Peptides Inhibit Cysteine Uptake and Decrease Glutathione in Human Neuronal Cells: Implications for the Redox/Methylation Theory of Autism. Friday, May 21, 2010Franklin Hall B Level 4 (Philadelphia Marriott Downtown)
(6) Jonathan Leonard, M.D., Gerald Haffenden, F.I.M.L.S., William Tucker, M.B., B.S., Joseph Unsworth, Ph.D., Frances Swain, M.B., B.S., Robert McMinn, M.D., Ph.D., John Holborow, M.D., and Lionel Fry, M.D. The Role of Gluten in Dermatitis Herpetiformis. N Engl J Med (1983) N Engl J Med 1983; 308:816-819April 7, 1983DOI: 10.1056/NEJM198304073081406

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